Pregabalin: its pharmacology and use in pain management.
نویسنده
چکیده
Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid. It is an alpha2-delta (alpha2-delta) ligand that has analgesic, anticonvulsant, anxiolytic, and sleep-modulating activities. Pregabalin binds potently to the alpha2-delta subunit of calcium channels, resulting in a reduction in the release of several neurotransmitters, including glutamate, noradrenaline, serotonin, dopamine, and substance P. In this review, I will discuss the pharmacology of pregabalin and available efficacy studies in pain management. This review will focus on the advances in pregabalin pharmacology since my previous review in 2005.
منابع مشابه
Evaluation of Antinociceptive Effect of Pregabalin in Mice and its Combination with Tramadol using Tail Flick Test
The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...
متن کاملEvaluation of Antinociceptive Effect of Pregabalin in Mice and its Combination with Tramadol using Tail Flick Test
The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...
متن کاملEvaluation of the efficacy of pregabalin on the treatment of patients with lumbosacral radiculopathy referring to Shahid Mofattah Yasuj Special Clinic
Background: Radiculopathy is defined as nerve root involvement and pressured that causes spinal pain. The problems of the lumbar and cervical disk herniation and diffusion pains are the most common problems in society so that 85% of people take low back pain at least once their life. These problems can be caused by herniated disc or spinal canal stenosis in the lumbar and cervical regions. The...
متن کاملبررسی اثرات پیش داروی پره گابالین در مقایسه با دارونما بر درد حاد پس از هیسترکتومی شکمی
Background and aims: Although pregabalin is primarily an anticonvulsive drug and is alsoeffective on chronic neuropathic pain, there are limited data regarding its effect on acute pain. Inthis study we assessed the analgesic effect of pregabalin on acute post operative pain used aspreemptive analgesia in comparison to placebo and compared pain intensity and opiumrequirements among placebo and p...
متن کاملA protocol for a systematic review for perioperative pregabalin use
BACKGROUND Perioperative pain management has recently been revolutionized with the recognition of novel mechanisms and introduction of newer drugs. Many randomized trials have studied the use of the gabapentinoid anti-epileptic, pregabalin, in acute pain. Published systematic reviews suggest that using pregabalin for perioperative pain management may decrease analgesic requirements and pain sco...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Anesthesia and analgesia
دوره 105 6 شماره
صفحات -
تاریخ انتشار 2007